okadaic acid - Swedish translation – Linguee

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It is a marine toxin produced by the genera of Prorocentrum and Dinophysis. Application Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor: • to inhibit protein phosphatase 2 in spermatocytes culture • to treat SH-SY5Y cells to prevent dephosphorylation to maintain tau Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae which causes diarrhetic shellfish poisoning. It is a selective and potent inhibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. The reduced activity of phospha … Okadaic acid as an inducer of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells. Hou MC(1), Shen CH, Lee WC, Lai YK. Author information: (1)Institute of Life Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. Okadaic acid is a causative agent of diarrhetic shellfish poisoning isolated from the sponge Halichondria Okadai.

Okadaic acid

Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC50s of 10-15 nM, 0.5 nM and 4 nM, respectively. Okadaic acid eliminate metazoan symbionts/parasites by apoptosis. - Mechanism of Action & Protocol. Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases.

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Okadaic acid sodium salt from Prorocentrum concavum. DTXSID00745585.

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Okadaic acid has also been described as a non-TPA type potent tumor promoter (4). These tumor-promoting properties and its ability to significantly increase protein phosphorylation make okadaic acid a very useful tool for studying cellular processes that are regulated by reversible phosphorylation of proteins (5). Molecular Formula: C 44 H 68 O 13 Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of Prorocentrum and Dinophysis. Application Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor: • to inhibit protein phosphatase 2 in spermatocytes culture • to treat SH-SY5Y cells to prevent dephosphorylation to maintain tau A potent inhibitor of certain serine/threonine protein phosphatases, targeting the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM); a very weak inhibitor of PP2B (IC50 > 2 µM); does not inhibit PP2C or other phosphatases.

Okadaic acid (or okadeic acid, CAS 78111-17-8, C44 H 68 O 13) is produced by dinoflagelates Dinophysis sp. and Prorocentrum lima. Lipophilic okadaic acid is a potent inhibitor of protein phosphorylase phosphatase-1 and -2A in the cytosol of the mammalian cells that dephosphorylates serine and threonine. Okadaic acid is an inhibitor of the serine/theorine protein phosphatases PP1 (IC 50 = 15-20 nM) and PP2A (IC 50 = 0.1 nM), exhibiting much greater activity towards the latter. PP2A is completely inhibited at 1-2 nM, compared to greater than 1 µM for PP1 (1). (3).
Engelsk fonetik lexikon

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 Okadaic Acid mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter.

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OKADAIC ACID - Dissertations.se

Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 ( PP1 ), PP2A and PP3 inhibitor with IC50 s of 10-15 nM, 0.5 nM and 4 nM, respectively. [1] [2] Okadaic acid eliminate metazoan symbionts/ parasites by apoptosis [3] . Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro.

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Add to favourites. Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp..Okadaic Acid is a reversible, potent and selective inhibitor of two serine threonine protein phosphatases: PP2A-C (PP2A) which is inhibited completely at 1 nM and PP1 which is inhibited at higher concentrations (IC 50 = 10-15 nM). Okadaic acid is a causative agent of diarrhetic shellfish poisoning isolated from the sponge Halichondria Okadai. Okadaic Acid exhibits various activities as follows: Contractile effect on smooth muscles in Ca 2+ free solution. Non-TPA type promoting agent of carcinogenesis.